• Home
  • About OPEN
    • OPEN Foundation
    • Objectives
    • Annual Reports
      • 2011 (pdf)
      • 2010 (pdf)
      • 2009 (pdf)
  • Activities
    • Agenda
    • Overview
    • Mind Altering Science
    • Ayahuasca Symposium
    • ICPR 2012
  • Psychedelics
    • Publications
      • Recent publications
      • By substance
        • 2C-B
        • Ketamine
        • 5-MeO-DMT
        • LSD
        • Ayahuasca
        • MDA
        • DMT
        • MDMA
        • DOB
        • Mescaline
        • DOI
        • Psilocybin
        • DOM
        • Salvinorin A
      • By field
        • Anthropology
        • Psychiatry
        • Chemistry
        • Psychology
        • History
        • Psychopharmacology
        • Medicine
        • Sociology
        • Neuroscience
      • By subject
        • Addiction
        • Depression
        • Altered perception
        • Mystical experiences
        • Anxiety disorder
        • Novel substances
        • Cluster headache
        • PTSD
        • Creativity
        • Safety
    • Videotheque
      • OPEN Videos
      • Documentaries
    • Library
      • Recent book releases
      • Freely available e-books
    • Links
      • Research
      • Informative
      • Databases
      • Politics
      • Other links
  • Support us
    • Donate
    • Volunteer
  • Webshop
  • Contact
     
     
     
     
     
     

OPEN Foundation

image

OPEN is a Dutch foundation that seeks to encourage interdisciplinary research into psychedelics.

Learn more

Support Us

Support OPEN and stimulate scientific research into psychedelics by making a donation.

Donate

Volunteer!

Do you have a fascination for psychedelics? OPEN Foundation is looking for volunteers!

Join us

Latest news

  • November 15, 2012

    Lecture Brussel: (Hoe) werken psychedelica?

    Stichting OPEN goes beyond it's limits with the Dutch lecture (Hoe) Werken Psychedelica? in the capital of our neighbouring country Belgium. In this lecture questions about the medicinal properties of psychedelics apart... Read more

  • October 14, 2012

    ICPR 2012 draws attention to psychedelic research

    On October 6 & 7, OPEN's second international conference took place in Amsterdam: the Interdisciplinary Conference on Psychedelic Research. In a sold out venue, over 400 researchers, students, therapists and scholars... Read more

  • August 14, 2012

    Study: no adverse effects in long-time ayahuasca users

    An investigation into the psychiatric and neuropsychological status of long-term ayahuasca users found no association between the long-term use of ayahuasca in a religious context and any mental health deficits. Read more

  • August 13, 2012

    Dutch plans for ibogaine research

    An article in the Dutch newspaper 'de Volkskrant' shows there are plans to study the effectiveness of ibogaine in the treatment of addiction in Nijmegen. Although ibogaine is used sporadically, there has been no scientific research in humans. Read more

  • July 19, 2012

    Danforth Research: Autism/Aspergian adults wanted

    Alicia Danforth, PhD student in clinical psychology at the Institute of Transpersonal Psychology, is looking for participants for her research into the therapeutic potential of MDMA as a support for autism spectrum social skills challenges. Read more

  • July 14, 2012

    MAPS Psychedelic Science 2013 Conference

    Four of the world's leading psychedelic research institutes will gather researchers, therapists, artists, and the curious over five days to share the latest research on MDMA, LSD, psilocybin, ayahuasca, ibogaine, and more. Read more

  • May 02, 2012

    First Names Public

    We are happy to announce some of the speakers of our conference. At the Interdisciplinary Conference on Psychedelic Research 2012 you can hear Dr. Robin Carhart-Harris, Dr. Matthew W. Johnson, Dr. Robin MacKenzie... Read more

  • February 16, 2012

    Psychedelic research in popular literature

    The Dutch KIJK magazine printed an article on research on psychedelics. “Tripping away your problems: a slow revival of drugs as medicine”. Reporter Jop de Vrieze interviewed scientists among whom psychiatrists Andrew Feldmár en Charles Grob... Read more

  • January 29, 2012

    New study may explain magic mushrooms' effects

    New research by a group of mainly Britisch scientists, based on fMRI brain scans, has shown that the use of psilocybin (the active constituent of magic mushrooms) decreases the activity of certain parts of the brain in test subjects. Read more

  • December 29, 2011

    Ayahuasca Scientific Literature Overview

    In response to the claims made in a 2010 communication with ICEERS by the United Nations International Narcotics Control Board regarding the 'serious health risks' associated with the intake of Ayahuasca, Psychologist and Ayahuasca... Read more

  • October 24, 2011

    Magic mushrooms can improve mental health

    According to new research by the Johns Hopkins School of Medicine in Baltimore, magic mushrooms can have long-lasting positive effects on people's well-being. After their use of the drug, volunteers reported positive effects such as... Read more

  • October 22, 2011

    Pre-announcement Mind Altering Science 2012

    OPEN is busy organising its second scientific conference on psychedelic research in the weekend of June 1-3: Mind Altering Science 2012. You can expect the latest results on research into MDMA, psilocybin, ayahuasca, LSD, ketamine ... Read more

  • September 15, 2011

    EARS Researcher Workgroup Report by MAPS Hungary

    In April 2011, over 300 people convened at the University of Amsterdam to attend the European Ayahuasca Research Symposium, a half-day seminar co-sponsored by The OPEN Foundation and MAPS. The Symposium brought... Read more

  • August 01, 2011

    Grant for new research on the positive effects of XTC

    Two neuropsychologists from the University of Maastricht, Jan Ramaekers and Kim Kuypers, have been granted €200.000 from the NWO, the Netherlands Organisation for Scientific Research. This will allow them to buy plenty of pills for... Read more

  • July 26, 2011

    EARS report by Simon Powell

    Last month in Amsterdam we held the European Ayahuasca Research Symposium, a one-day lecture series exploring the current state of research into the medical, therapeutic, and spiritual uses of ayahuasca. Simon Powell, author of... Read more

  • May 19, 2011

    European Ayahuasca Research Symposium

    The European Ayahuasca Research Symposium is a multidisciplinary series of lectures that focuses on current research being done in Europe. Experts from different disciplines will present their studies on ayahuasca’s effects on health... Read more

  • May 16, 2011

    LSD documentary night Amsterdam

    The LSD documentary night returns, this time to our hometown Amsterdam. This evening features two documentaries: Hofmann's Potion and LSD: Problem Child and Wonder Drug. Both documentaries offer a special view on one of... Read more

  • May 05, 2011

    Rick Strassman Interview

    Weblog boingboing has published an interview with psychiatrist Rick Strassman. He was the first scientist to conduct U.S. government-approved human research into hallucinogens and psychedelic drugs after the so-called... Read more

  • April 18, 2011

    Wanted: participants for survey

    Do you take drugs to heighten your spirituality? Read on! We are looking for participants for a new survey regarding the relationship between drugs and spirituality. The research focuses on all kinds of drugs, from alcohol and cocaine to LSD. Read more

  • April 11, 2011

    Psilocybin cuts brain blood flow and connections

    Psychedelic drug users throughout the ages have described their experiences as mind-expanding. They might be surprised, therefore, to hear that psilocybin – the active ingredient in magic mushrooms – actually decreases blood flow... Read more

  • March 28, 2011

    Medical Psychedelics - Soma for the masses?

    Are psychedelics and entheogens medicines and/or spiritual tools for consciousness expansion? Can they be culture jammed by Big Pharma into commodified weapons of mass control, a soma for the masses? Find out the answers as... Read more

  • March 18, 2011

    Prehistoric mushroom use in Spain

    Europeans may have used magic mushrooms to liven up religious rituals 6000 years ago. So suggests a cave mural in Spain, which may depict fungi with hallucinogenic properties - the oldest evidence of their use in Europe. The Selva... Read more

  • March 12, 2011

    New website launched

    After months of hard work, it is finally finished: our completely renewed website. A cleaner layout, improved navigation and many new features: search functionality, the option to view the website in English, a video library with recordings of OPEN... Read more

  • March 10, 2011

    New Shulgin book published!

    We mentioned it earlier on our website, a new book by Alexander Shulgin (from PiHKAL and TiHKAL) was on its way. And now, the moment has arrived! The Shulgin Index, the new book by Alexander Shulgin, Tania Manning and... Read more

Banner

New videos

  • April 16, 2013

    Labyrint: Mindblowing Therapy?

    Will we be using Magic Mushrooms to fight depression? Or go to the pharmacy to get an LSD treatment to cure your smoking addiction? Labyrint TV aired an episode about groundbreaking research using psychedelics in psychiatric treatment. Watch here

  • December 28, 2012

    ICPR 2012: Robin Carhart-Harris

    This talk will describe recently completed fMRI and MEG research with psilocybin and MDMA. I will describe the methods and main results of these studies and discuss their potential implications, both for understanding how the drugs work... Watch here

  • December 28, 2012

    ICPR 2012: Matthew Johnson

    This talk will describe several lines of research with psilocybin conducted by our laboratory at Johns Hopkins (Baltimore, USA). Completed study results to be presented include: the effects of different psilocybin doses on mystical experience... Watch here

  • May 19, 2012

    EARS: Jörg Daumann

    Deficits in attentional functions are counted among the core cognitive symptoms in schizophrenic patients. Pharmacologic challenges with hallucinogens have been used as models for psychosis. In this talk I give an overview of... Watch here

  • May 19, 2012

    EARS: Brian Anderson

    This presentation analyzes from an anthropological perspective some of the ways that ayahuasca’s curative potentials have been portrayed in conventional psychiatry from the 1950s until today. Through considering seldom-cited and... Watch here

  • May 19, 2012

    EARS: Rama Leclerc

    The Shipibo-Konibo people from the Peruvian Amazon are part of the Pano ethnolinguistic family. Distributed within more than one hundred villages, the inhabitants live along the Ucayali River and its tributaries, on both sides of... Watch here

  • May 19, 2012

    EARS: Petra Bokor

    The presentation starts with an overview of the research on the psychotherapeutic effects of ayahuasca and presents in details an investigation into the integration process of ayahuasca experiences. Eleven individuals... Watch here

  • May 19, 2012

    EARS: Janine Schmid

    The often used term ‘healing ritual’ for nearly all kinds of ayahuasca rituals (Santo Daime rituals, neo-shamanistic rituals and even do-it-yourself-rituals) attracts people searching for an alternative method for treatment. In this study, fifteen people with... Watch here

  • April 28, 2012

    Mind Altering Science: Torsten Passie

    Dr. Passie completed his training as a specialist in psychiatry and psychotherapy as well as his academic work at the Psychiatric University Hospital Zurich, in practice by Prof. Hans Carl Leuner in Göttingen and Hannover Medical School. Watch here

  • April 20, 2012

    Mind Altering Science: Joe Bicknell

    Psychedelic phenomenology deals with the phenomenal content of psychedelic tripping, thus phenomenology approaches psychedelics from the reverse direction of the scientific approach, because instead of looking at the structures of... Watch here

  • April 20, 2012

    Mind Altering Science: David Luke

    The Amazonian sacramental decoction, ayahuasca (containing an alkaloid once called telepathine by Westerners), has been used by indigenous shamans and healers for several millennia. Apparently, for the explicit purposes of accessing altered states... Watch here

  • April 20, 2012

    Mind Altering Science: Konstantin Kuteykin-Teplyakov

    Molecules of mysticism” are chemical substances that are able to induce mystical experience, increasing the feeling of closeness to the god (entheogens) or to other people (empathogens). It is quite likely, that every mystical experience is mediated... Watch here

  • March 30, 2012

    Mind Altering Science: Klaas Pieter van der Tempel

    How does the psychedelic experience affect the knowledge and motivation of the scientist? And what does this mean for academia in general? To answer such questions, this presentation will focus on the master's thesis... Watch here

  • October 22, 2011

    Mind Altering Science: Jazmin Wuyts

    In 2007, as part of the MA Cultural Anthropology, I have done research amongst the members of the Santo Daime church in Florianópolis (Brazil) and in The Hague. In their ceremonies they use ayahuasca, sometimes combined with cannabis... Watch here

  • October 22, 2011

    Mind Altering Science: Anwar Jeewa

    It has become increasingly difficult to assist an individual to maintain long term recovery from substance abuse. This is frustrating to individuals, their families and also to service providers. The reason for this trend is not absolutely clear. Over... Watch here

  • October 22, 2011

    Mind Altering Science: Katharina Kirchner

    After more than 40 years the first study employing LSD in psychotherapy is being conducted in Switzerland. 12 persons suffering from a life-threatening disease and an anxiety disorder are having the possibility to receive 200µg of LSD in a... Watch here

Banner

Select your language

Newsletter

OPEN Agenda

MAY
28

28.05.2013 - 02.06.2013
Science and Nonduality Conference - The Science and Mystery of Perception

JUN
04

04.06.2013 20:00 - 23:30
OPEN borrel - East of Eden

Full agenda

Recent publications

Hallucinogen persisting perception disorder: what do we know after 50 years?

Abstract 'Flashbacks' following use of hallucinogenic drugs have been reported for decades; they are recognized in DSM-IV as 'Hallucinogen Persisting Perception Disorder (Flashbacks)', or HPPD. We located...

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity

Abstract N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine...

In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in MDMA and Hallucinogen Users

Context: Both hallucinogens and 3,4-methylenedioxy-methamphetamine (MDMA or “ecstasy”) have direct agonistic effects on postsynaptic serotonin 2A receptors, the key site for hallucinogenic actions....

The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions

Rationale Both glutamate and serotonin (5-HT) play a key role in the pathophysiology of emotional biases. Recent studies indicate that the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine...
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8

User Panel

  • Forgot your password?
  • Forgot your username?
  • Create an account