Since Domino and colleagues1 reported the first clinical use of ketamine more than half a century ago, there have been many clinical and laboratory studies to determine both mechanism(s) of action and the most appropriate clinically useful properties of this enigmatic drug. These include analgesia, favourable cardiorespiratory profile, anti-inflammatory effects, and anticancer actions.2–4 In addition, antidepressant actions of ketamine have been recognised that are of clinical applicability.5–7 In psychiatry, many clinical studies demonstrate that existing antidepressant medications show limited effectiveness and slow onset of clinical response.
Hirota, K. and Lambert, D. (2018). Ketamine and depression. British Journal of Anaesthesia, 121(6), pp.1198-1202., 10.1016/j.bja.2018.08.020